Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation

We report the x-ray structures of several bisphosphonate inhibitors of geranylgeranyl diphosphate synthase, a target for anti-cancer drugs. Bisphosphonates containing unbranched sidechains bind to either the farnesyl diphosphate (FPP) substrate site, the geranylgeranyl diphosphate (GGPP) product sit...

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Autors principals: Chen, Cammy K.-M., Hudock, Michael P., Zhang, Yonghui, Guo, Rey-Ting, Cao, Rong, No, Joo Hwan, Liang, Po-Huang, Ko, Tzu-Ping, Chang, Tao-Hsin, Chang, Shiou-chi, Song, Yongcheng, Axelson, Jordan, Kumar, Anup, Wang, Andrew H.-J., Oldfield, Eric
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2552397/
https://ncbi.nlm.nih.gov/pubmed/18800762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800325y
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