Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase (GGPPS), as well as undec...

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Autori principali: Guo, Rey-Ting, Cao, Rong, Liang, Po-Huang, Ko, Tzu-Ping, Chang, Tao-Hsin, Hudock, Michael P., Jeng, Wen-Yih, Chen, Cammy K.-M., Zhang, Yonghui, Song, Yongcheng, Kuo, Chih-Jung, Yin, Fenglin, Oldfield, Eric, Wang, Andrew H.-J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877987/
https://ncbi.nlm.nih.gov/pubmed/17535895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702254104
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