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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase (GGPPS), as well as undec...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1877987/ https://ncbi.nlm.nih.gov/pubmed/17535895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702254104 |
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