Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase (GGPPS), as well as undec...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Guo, Rey-Ting, Cao, Rong, Liang, Po-Huang, Ko, Tzu-Ping, Chang, Tao-Hsin, Hudock, Michael P., Jeng, Wen-Yih, Chen, Cammy K.-M., Zhang, Yonghui, Song, Yongcheng, Kuo, Chih-Jung, Yin, Fenglin, Oldfield, Eric, Wang, Andrew H.-J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877987/
https://ncbi.nlm.nih.gov/pubmed/17535895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702254104
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki