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Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias

Chronic myelogenous leukemia is a myeloproliferative disorder (MPD) that, over time, progresses to acute leukemia. Both processes are closely associated with the t(9;22) chromosomal translocation that creates the BCR/ABL fusion gene in hematopoietic stem cells (HSCs) and their progeny. Chronic myelo...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Jaiswal, Siddhartha, Traver, David, Miyamoto, Toshihiro, Akashi, Koichi, Lagasse, Eric, Weissman, Irving L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187741/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12890867/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1633833100
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