Vav1 Acidic Region Tyrosine 174 Is Required for the Formation of T Cell Receptor-induced Microclusters and Is Essential in T Cell Development and Activation

Vav proteins are multidomain signaling molecules critical for mediating signals downstream of several surface receptors, including the antigen receptors of T and B lymphocytes. The catalytic guanine nucleotide exchange factor (GEF) activity of the Vav Dbl homology (DH) domain is thought to be contro...

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Main Authors: Miletic, Ana V., Sakata-Sogawa, Kumiko, Hiroshima, Michio, Hamann, Michael J., Gomez, Timothy S., Ota, Naruhisa, Kloeppel, Tracie, Kanagawa, Osami, Tokunaga, Makio, Billadeau, Daniel D., Swat, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876972/
https://ncbi.nlm.nih.gov/pubmed/17050525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608913200
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