Vav Links the T Cell Antigen Receptor to the Actin Cytoskeleton and T Cell Activation Independently of Intrinsic Guanine Nucleotide Exchange Activity

BACKGROUND: T cell receptor (TCR) engagement leads to formation of signaling microclusters and induction of rapid and dynamic changes in the actin cytoskeleton, although the exact mechanism by which the TCR initiates actin polymerization is incompletely understood. The Vav family of guanine nucleoti...

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Detalhes bibliográficos
Main Authors: Miletic, Ana V., Graham, Daniel B., Sakata-Sogawa, Kumiko, Hiroshima, Michio, Hamann, Michael J., Cemerski, Saso, Kloeppel, Tracie, Billadeau, Daniel D., Kanagawa, Osami, Tokunaga, Makio, Swat, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719804/
https://ncbi.nlm.nih.gov/pubmed/19672294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006599
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