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DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter
The gene encoding the ABCC6 protein, an ABC transporter of the multidrug resistance-associated protein (MRP), is mainly expressed in liver and kidney. Mutations in ABCC6 are responsible for the development of the pseudoxanthoma elasticum (PXE) phenotype. PXE is a recessive disease characterized by t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1876782/ https://ncbi.nlm.nih.gov/pubmed/17214963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.12.151 |
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