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DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter

The gene encoding the ABCC6 protein, an ABC transporter of the multidrug resistance-associated protein (MRP), is mainly expressed in liver and kidney. Mutations in ABCC6 are responsible for the development of the pseudoxanthoma elasticum (PXE) phenotype. PXE is a recessive disease characterized by t...

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Bibliografske podrobnosti
Main Authors: Douet, Vanessa, Heller, Matthew B., Le Saux, Olivier
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876782/
https://ncbi.nlm.nih.gov/pubmed/17214963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.12.151
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