Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers

AIMS: To assess the pharmacokinetic and pharmacodynamic profile of the novel PDE4 inhibitor V11294A (3-(3-cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H purine hydrochloride) in healthy male volunteers. METHODS: This was a double-blind, single dose, randomized crossover study in eight h...

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Detalhes bibliográficos
Main Authors: Gale, Donna Donigi, Landells, Linda J, Spina, Domenico, Miller, Alan J, Smith, Kate, Nichols, Terry, Rotshteyn, Yakov, Tonelli, Alfred, Lacouture, Peter, Burch, Ronald M, Page, Clive P, O'Connor, Brian J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874476/
https://ncbi.nlm.nih.gov/pubmed/12445026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01682.x
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