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Phosphodiesterase inhibitors

Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and thus play a key role in regulating intracellular levels of the second messengers cAMP and cGMP, and hence cell function. Theophylline and papaverine have historically been used therapeutically and are known to b...

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Autors principals: Boswell-Smith, Victoria, Spina, Domenico, Page, Clive P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1760738/
https://ncbi.nlm.nih.gov/pubmed/16402111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706495
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