Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

Nonhomologous end-joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks (DSBs) in mammalian cells. The DNA-dependent protein kinase (DNA-PK), consisting of Ku and DNA-PK catalytic subunit (DNA-PKcs), is activated by DNA in vitro and is required for NHEJ. We report that DNA-...

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Библиографические подробности

Опубликовано в::	Genes Dev
Главные авторы:	Chan, Doug W., Chen, Benjamin Ping-Chi, Prithivirajsingh, Sheela, Kurimasa, Akihiro, Story, Michael D., Qin, Jun, Chen, David J.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Cold Spring Harbor Laboratory Press 2002
Предметы:	Research Communication
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187438/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12231622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1015202
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