Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

Nonhomologous end-joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks (DSBs) in mammalian cells. The DNA-dependent protein kinase (DNA-PK), consisting of Ku and DNA-PK catalytic subunit (DNA-PKcs), is activated by DNA in vitro and is required for NHEJ. We report that DNA-...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Genes Dev
Hauptverfasser:	Chan, Doug W., Chen, Benjamin Ping-Chi, Prithivirajsingh, Sheela, Kurimasa, Akihiro, Story, Michael D., Qin, Jun, Chen, David J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2002
Schlagworte:	Research Communication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187438/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12231622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1015202
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!