Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

Nonhomologous end-joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks (DSBs) in mammalian cells. The DNA-dependent protein kinase (DNA-PK), consisting of Ku and DNA-PK catalytic subunit (DNA-PKcs), is activated by DNA in vitro and is required for NHEJ. We report that DNA-...

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Bibliographic Details
Main Authors: Chan, Doug W., Chen, Benjamin Ping-Chi, Prithivirajsingh, Sheela, Kurimasa, Akihiro, Story, Michael D., Qin, Jun, Chen, David J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2002
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC187438/
https://ncbi.nlm.nih.gov/pubmed/12231622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1015202
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