The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine

AIMS: To examine the stereoselective disposition of chlorpheniramine and to evaluate the role of CYP2D6 in chlorpheniramine pharmacokinetics in humans. METHODS: Eight healthy volunteers (six extensive metabolizers with respect to CYP2D6 and two poor metabolizers) received a single 8 mg oral dose of...

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Библиографические подробности
Главные авторы: Yasuda, Sally Usdin, Zannikos, Peter, Young, Andrea E, Fried, Karen M, Wainer, Irving W, Woosley, Raymond L
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2002
Предметы:
Drug Disposition
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874352/
https://ncbi.nlm.nih.gov/pubmed/11994058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01578.x
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