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The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil citrate

AIMS: To investigate the effects of age and renal and hepatic impairment on the pharmacokinetics, tolerability and safety of sildenafil (single 50-mg oral dose) and its major circulating N-desmethyl metabolite, UK-103,320. METHODS: Three open-label, parallel-group studies were conducted. The first s...

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Bibliografiske detaljer
Main Authors: Muirhead, Gary J, Wilner, Keith, Colburn, Wayne, Haug-Pihale, Gertrude, Rouviex, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874252/
https://ncbi.nlm.nih.gov/pubmed/11879256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.00029.x
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