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The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers

AIMS: Sildenafil, an effective oral treatment for erectile dysfunction, is predominantly metabolized by the cytochrome P450 isozyme 3A4, which is inhibited by a number of the macrolide antibiotics. Therefore, two placebo-controlled, parallel-group studies were conducted to evaluate the effects of mu...

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書誌詳細
主要な著者: Muirhead, Gary J, Faulkner, Stephen, Harness, Jane A, Taubel, Jörg
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874259/
https://ncbi.nlm.nih.gov/pubmed/11879258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.00031.x
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