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The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers
AIMS: Sildenafil, an effective oral treatment for erectile dysfunction, is predominantly metabolized by the cytochrome P450 isozyme 3A4, which is inhibited by a number of the macrolide antibiotics. Therefore, two placebo-controlled, parallel-group studies were conducted to evaluate the effects of mu...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Science Inc
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1874259/ https://ncbi.nlm.nih.gov/pubmed/11879258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.00031.x |
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