Tumor Necrosis Factor Alpha Is a Key Mediator of Gut Inflammation Seen in Amebic Colitis in Human Intestine in the SCID Mouse-Human Intestinal Xenograft Model of Disease

We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α) in the pathogenesis of amebic colitis. We found that blockade of TNF-α reduced inflammation and intestinal damage in amebic infection, while inhibiti...

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Pubblicato in:	Infect Immun
Autori principali:	Zhang, Zhi, Mahajan, Sajan, Zhang, Xiaochung, Stanley, Samuel L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Fungal and Parasitic Infections
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12933883/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.9.5355-5359.2003
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