Tumor Necrosis Factor Alpha Is a Key Mediator of Gut Inflammation Seen in Amebic Colitis in Human Intestine in the SCID Mouse-Human Intestinal Xenograft Model of Disease

We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α) in the pathogenesis of amebic colitis. We found that blockade of TNF-α reduced inflammation and intestinal damage in amebic infection, while inhibiti...

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Detalhes bibliográficos
Principais autores: Zhang, Zhi, Mahajan, Sajan, Zhang, Xiaochung, Stanley, Samuel L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC187299/
https://ncbi.nlm.nih.gov/pubmed/12933883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.9.5355-5359.2003
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