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A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3′-UTR
Selenocysteine insertion into protein in mammalian cells requires RNA elements in the 3′-untranslated regions (3′-UTRs) of selenoprotein genes. The occurrence of these conserved sequences should make selenoproteins particularly amenable for knockdown/knock-in strategies to examine selenoprotein func...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1869036/ https://ncbi.nlm.nih.gov/pubmed/17468436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.533007 |
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