Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

β(2)-ARs (β(2)-adrenoceptors) become desensitized rapidly upon recruitment of cytosolic β-arrestin. PDE4D5 (family 4 cAMP-specific phosphodiesterase, subfamily D, isoform 5) can be recruited in complex with β-arrestin, whereupon it regulates PKA (cAMP-dependent protein kinase) phosphorylation of the...

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Detalles Bibliográficos
Main Authors: Baillie, George S., Adams, David R., Bhari, Narinder, Houslay, Thomas M., Vadrevu, Suryakiran, Meng, Dong, Li, Xiang, Dunlop, Allan, Milligan, Graeme, Bolger, Graeme B., Klussmann, Enno, Houslay, Miles D.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868836/
https://ncbi.nlm.nih.gov/pubmed/17288540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070005
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