Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

We have previously shown that expression of a dominant-negative type II transforming growth factor-β receptor (DNIIR) in mammary epithelium under control of the MMTV promoter/enhancer causes alveolar hyperplasia and differentiation in virgin mice. Here we show that MMTV-DNIIR female mice have accele...

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Main Authors: Gorska, Agnieszka E., Jensen, Roy A., Shyr, Yu, Aakre, Mary E., Bhowmick, Neil A., Moses, Harold L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2003
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868288/
https://ncbi.nlm.nih.gov/pubmed/14507660
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