Effects of BRCA1 Transgene Expression on Murine Mammary Gland Development and Mutagen-Induced Mammary Neoplasia

To characterize the role of BRCA1 in mammary gland development and tumor suppression, a transgenic mouse model of BRCA1 overexpression was developed. Using the mouse mammary tumor virus (MMTV) promoter/enhancer, transgenic mice expressing human BRCA1 or select mutant controls were generated. Transge...

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Hauptverfasser: Hoshino, Arichika, Yee, Cindy J., Campbell, Mel, Woltjer, Randall L., Townsend, Rebecca L., van der Meer, Riet, Shyr, Yu, Holt, Jeffrey T., Moses, Harold L., Jensen, Roy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2007
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865089/
https://ncbi.nlm.nih.gov/pubmed/17505536
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