Mammary Tumorigenesis following Transgenic Expression of a Dominant Negative CHK2 Mutant

A truncating allele of the cell cycle checkpoint kinase CHK2 is present in 1% of the population, conferring a moderate increase in breast cancer risk, and inactivation of chk2 enhances mammary tumorigenesis in mice with targeted inactivation of brca1. We used the mouse mammary tumor virus (MMTV) pro...

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Bibliographic Details
Main Authors:	Kwak, Eunice L., Kim, Sang, Zhang, Jianmin, Cardiff, Robert D., Schmidt, Emmett V., Haber, Daniel A.
Format:	Artigo
Language:	Inglês
Published:	2006
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2865171/ https://ncbi.nlm.nih.gov/pubmed/16488990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-1237
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Mammary Tumorigenesis following Transgenic Expression of a Dominant Negative CHK2 Mutant

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