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Mammary Tumorigenesis following Transgenic Expression of a Dominant Negative CHK2 Mutant
A truncating allele of the cell cycle checkpoint kinase CHK2 is present in 1% of the population, conferring a moderate increase in breast cancer risk, and inactivation of chk2 enhances mammary tumorigenesis in mice with targeted inactivation of brca1. We used the mouse mammary tumor virus (MMTV) pro...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865171/ https://ncbi.nlm.nih.gov/pubmed/16488990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-1237 |
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