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Antisense Oligonucleotides Against Thrombospondin-1 Inhibit Activation of TGF-β in Fibrotic Renal Disease in the Rat in Vivo

Specific treatment of chronic progressive renal disease is very limited. TGF-β, considered as the major cytokine causing tissue scarring, must be activated extracellularly before it can bind to its receptors. Thrombospondin-1 (TSP1) has been identified as an activator of latent TGF-β in in vitro sys...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Daniel, Christoph, Takabatake, Yoshitugu, Mizui, Masayuki, Isaka, Yoshitaka, Kawashi, Hiroshi, Rupprecht, Harald, Imai, Enyu, Hugo, Christian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868256/
https://ncbi.nlm.nih.gov/pubmed/12937160
Tagiau: Ychwanegu Tag
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