Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor

Duchenne muscular dystrophy (DMD) is caused by lack of functional dystrophin and results in progressive myofiber damage and degeneration. In addition, impaired muscle regeneration and fibrosis contribute to the progressive pathology of DMD. Importantly, transforming growth factor-β (TGF-β) is implic...

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Hlavní autoři: Kemaladewi, Dwi U, Pasteuning, Svitlana, van der Meulen, Joke W, van Heiningen, Sandra H, van Ommen, Gert-Jan, ten Dijke, Peter, Aartsma-Rus, Annemieke, ‘t Hoen, Peter AC, Hoogaars, Willem M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011125/
https://ncbi.nlm.nih.gov/pubmed/24691207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.7
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