The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

We have used spectral karyotyping to assess potential roles of three different components of the nonhomologous DNA end-joining pathway in the maintenance of genomic stability in mouse embryonic fibroblasts (MEFs). MEFs homozygous for mutations that inactivate either DNA ligase IV (Lig4) or Ku70 disp...

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Detalhes bibliográficos
Main Authors: Ferguson, David O., Sekiguchi, JoAnn M., Chang, Sandy, Frank, Karen M., Gao, Yijie, DePinho, Ronald A., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18682/
https://ncbi.nlm.nih.gov/pubmed/10823907
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