The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.
Telomeres distinguish chromosome ends from double-strand breaks (DSBs) and prevent chromosome fusion. However, telomeres can also interfere with DNA repair, as shown by a deficiency in nonhomologous end joining (NHEJ) and an increase in large deletions at telomeric DSBs. The sensitivity of telomeric...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2013-03-01
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| Serier: | PLoS Genetics |
| Online adgang: | http://europepmc.org/articles/PMC3610639?pdf=render |
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