PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-β/EGFR signaling promotes cell migration and induces expression of both...

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Main Authors: Wilkins-Port, Cynthia E., Higgins, Craig E., Freytag, Jennifer, Higgins, Stephen P., Carlson, J. Andrew, Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2007
Assuntos:
Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868077/
https://ncbi.nlm.nih.gov/pubmed/17515947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2007/85208
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