Detection of the Activating JAK2 V617F Mutation in Paraffin-Embedded Trephine Bone Marrow Biopsies of Patients with Chronic Myeloproliferative Diseases

The discovery of the activating V617F mutation in the JAK2 tyrosine kinase in a high proportion of patients with Ph− chronic myeloproliferative diseases (CMPD) represents a diagnostic breakthrough for these disorders. Trephine bone marrow biopsy is an essential part of the diagnostic workup of CMPD...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Horn, Thomas, Kremer, Marcus, Dechow, Tobias, Pfeifer, Walther M., Geist, Birgit, Perker, Michael, Duyster, Justus, Quintanilla-Martinez, Leticia, Fend, Falko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2006
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867602/
https://ncbi.nlm.nih.gov/pubmed/16825501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.050128
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