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JAK2 and Beyond: JAK2V617 Mutational Study of Myeloproliferative Disorders and Haematological Malignancies
BACKGROUND: Janus Tyrosine Kinase-2 (JAK2 V617F), a novel point mutation affecting the MPD’S is a somatic gain-of-function mutation. It alters a highly conserved amino acid valine in the negative regulatory JH2 domain to phenylalanine predicted to dysregulate kinase activity. AIM: To evaluate the pr...
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| Publicado no: | Asian Pac J Cancer Prev |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
West Asia Organization for Cancer Prevention
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7173381/ https://ncbi.nlm.nih.gov/pubmed/31870101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.31557/APJCP.2019.20.12.3611 |
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