γ-Glutamyl Transpeptidase-Deficient Mice Are Resistant to the Nephrotoxic Effects of Cisplatin

We have proposed that the nephrotoxicity of cisplatin, a widely used chemotherapy drug, is the result of the binding of cisplatin to glutathione and the subsequent metabolism of the cisplatin-glutathione complex via a γ-glutamyl transpeptidase (GGT)-dependent pathway in the proximal tubules. To test...

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Autors principals: Hanigan, Marie H., Lykissa, Ernest D., Townsend, Danyelle M., Ou, Ching-Nan, Barrios, Roberto, Lieberman, Michael W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2001
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867073/
https://ncbi.nlm.nih.gov/pubmed/11696449
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