High-Frequency Epigenetic Repression and Silencing of Retroviruses Can Be Antagonized by Histone Deacetylase Inhibitors and Transcriptional Activators, but Uniform Reactivation in Cell Clones Is Restricted by Additional Mechanisms

Integrated retroviral DNA is subject to epigenetic gene silencing, but the viral and host cell properties that influence initiation, maintenance, and reactivation are not fully understood. Here we describe rapid and high-frequency epigenetic repression and silencing of integrated avian sarcoma virus...

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Hlavní autoři: Katz, Richard A., Jack-Scott, Emily, Narezkina, Anna, Palagin, Ivan, Boimel, Pamela, Kulkosky, Joseph, Nicolas, Emmanuelle, Greger, James G., Skalka, Anna Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866008/
https://ncbi.nlm.nih.gov/pubmed/17202206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01643-06
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