High-Frequency Epigenetic Repression and Silencing of Retroviruses Can Be Antagonized by Histone Deacetylase Inhibitors and Transcriptional Activators, but Uniform Reactivation in Cell Clones Is Restricted by Additional Mechanisms

Integrated retroviral DNA is subject to epigenetic gene silencing, but the viral and host cell properties that influence initiation, maintenance, and reactivation are not fully understood. Here we describe rapid and high-frequency epigenetic repression and silencing of integrated avian sarcoma virus...

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Main Authors: Katz, Richard A., Jack-Scott, Emily, Narezkina, Anna, Palagin, Ivan, Boimel, Pamela, Kulkosky, Joseph, Nicolas, Emmanuelle, Greger, James G., Skalka, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866008/
https://ncbi.nlm.nih.gov/pubmed/17202206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01643-06
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