Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code

Retrovirus vectors are de novo methylated and transcriptionally silent in mammalian stem cells. Here, we identify epigenetic modifications that mark retrovirus-silenced transgenes. We show that murine stem cell virus (MSCV) and human immunodeficiency virus type 1 (HIV-1) vectors dominantly silence a...

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Main Authors: Pannell, Dylan, Osborne, Cameron S., Yao, Shuyuan, Sukonnik, Tanya, Pasceri, Peter, Karaiskakis, Angelo, Okano, Masaki, Li, En, Lipshitz, Howard D., Ellis, James
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2000
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC305782/
https://ncbi.nlm.nih.gov/pubmed/11060039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5884
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