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Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code
Retrovirus vectors are de novo methylated and transcriptionally silent in mammalian stem cells. Here, we identify epigenetic modifications that mark retrovirus-silenced transgenes. We show that murine stem cell virus (MSCV) and human immunodeficiency virus type 1 (HIV-1) vectors dominantly silence a...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305782/ https://ncbi.nlm.nih.gov/pubmed/11060039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5884 |
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