Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8(+) antiviral T-cell exhaustion and may contrib...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Radziewicz, Henry, Ibegbu, Chris C., Fernandez, Marina L., Workowski, Kimberly A., Obideen, Kamil, Wehbi, Mohammad, Hanson, Holly L., Steinberg, James P., Masopust, David, Wherry, E. John, Altman, John D., Rouse, Barry T., Freeman, Gordon J., Ahmed, Rafi, Grakoui, Arash
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2007
Θέματα:
Pathogenesis and Immunity
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865979/
https://ncbi.nlm.nih.gov/pubmed/17182670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02021-06
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