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Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8(+) antiviral T-cell exhaustion and may contrib...

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Autors principals: Radziewicz, Henry, Ibegbu, Chris C., Fernandez, Marina L., Workowski, Kimberly A., Obideen, Kamil, Wehbi, Mohammad, Hanson, Holly L., Steinberg, James P., Masopust, David, Wherry, E. John, Altman, John D., Rouse, Barry T., Freeman, Gordon J., Ahmed, Rafi, Grakoui, Arash
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865979/
https://ncbi.nlm.nih.gov/pubmed/17182670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02021-06
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