Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8(+) antiviral T-cell exhaustion and may contrib...

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Detalhes bibliográficos
Main Authors: Radziewicz, Henry, Ibegbu, Chris C., Fernandez, Marina L., Workowski, Kimberly A., Obideen, Kamil, Wehbi, Mohammad, Hanson, Holly L., Steinberg, James P., Masopust, David, Wherry, E. John, Altman, John D., Rouse, Barry T., Freeman, Gordon J., Ahmed, Rafi, Grakoui, Arash
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865979/
https://ncbi.nlm.nih.gov/pubmed/17182670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02021-06
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