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Acquired Transcriptional Programming in Functional and Exhausted Virus-specific CD8 T Cells

PURPOSE OF REVIEW: Failure to control viral infections such as HIV, results in TCR and inhibitory receptor driven exhaustion of antigen-specific T cells. Persistent signaling by these receptors during chronic viral infection sculpts the transcriptional regulatory programs of virus-specific T cells....

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Detalhes bibliográficos
Main Authors: Youngblood, Ben, Wherry, E. John, Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306172/
https://ncbi.nlm.nih.gov/pubmed/22134341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COH.0b013e32834ddcf2
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