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EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants

We have examined the role of checkpoint pathways in responding to a yku70Δ defect in budding yeast. We show that CHK1, MEC1, and RAD9 checkpoint genes are required for efficient cell cycle arrest of yku70Δ mutants cultured at 37°C, whereas RAD17, RAD24, MEC3, DDC1, and DUN1 play insignificant roles....

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Bibliografiske detaljer
Udgivet i:Genes Dev
Principais autores: Maringele, Laura, Lydall, David
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2002
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186411/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12154123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.225102
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