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Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21(WAF1/CIP1)

Angiogenesis has been demonstrated to be essential for tumor growth and metastasis, and inhibition of angiogenesis is emerging as a promising strategy for treating cancer. Among the most potent inhibitors of angiogenesis is the fumagillin family of natural products. An analog of fumagillin, known as...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Yi, Griffith, Eric C., Sage, Julien, Jacks, Tyler, Liu, Jun O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18619/
https://ncbi.nlm.nih.gov/pubmed/10841547
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