Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe

The chromosome end-replicating enzyme telomerase is composed of a template-containing RNA subunit, a reverse transcriptase (TERT), and additional proteins. The importance of conserved amino acid residues in Trt1p, the TERT of Schizosaccharomyces pombe, was tested. Mutation to alanine of the proposed...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Haering, Christian H., Nakamura, Toru M., Baumann, Peter, Cech, Thomas R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18609/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.130187397
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