Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins.

In vivo perfusion of canine testes with ketoconazole inhibited the stimulation of testosterone production by human chorionic gonadotropin in a dose-dependent manner. Ketoconazole also selectively displaced steroids from serum-binding globulins. Dihydrotestosterone and estradiol binding to sex hormon...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Grosso, D S, Boyden, T W, Pamenter, R W, Johnson, D G, Stevens, D A, Galgiani, J N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1983
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6301363/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.23.2.207
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