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A mouse model for the delta F508 allele of cystic fibrosis.

The most common cause of cystic fibrosis is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance regulator (CFTR). The delta F508 protein is misprocessed and degraded rather than traveling to the apical membrane. We used a novel strategy to introduce the delta F508...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:J Clin Invest
Hauptverfasser: Zeiher, B G, Eichwald, E, Zabner, J, Smith, J J, Puga, A P, McCray, P B, Capecchi, M R, Welsh, M J, Thomas, K R
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1995
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185844/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7560099/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118253
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