Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state
γ-Secretase is a membrane-associated protease that cleaves within the transmembrane region of amyloid precursor protein to generate the C termini of the two Aβ peptide isoforms, Aβ40 and Aβ42. Here we report the detergent solubilization and partial characterization of γ-secretase. The activity of so...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18571/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10801983/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110126897 |
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