FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex

To investigate the mechanism of regulation of Aß production by familial Alzheimer's disease (FAD)-linked presenilin 1 (PS1), we used a cell-free system that allows de novo Aß generation to examine whether PS1 participates directly in the γ-secretase reaction. Optimal Aß generation in vitro was achie...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Weiming Xia, Beth L. Ostaszewski, W.Taylor Kimberly, Talat Rahmati, Chad L. Moore, Michael S. Wolfe, Dennis J. Selkoe
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2000-12-01
Sarja:	Neurobiology of Disease
Linkit:	http://www.sciencedirect.com/science/article/pii/S096999610090322X
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