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Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Generation of Aβ from the β-amyloid precursor protein (APP) requires a series of proteolytic processes, including an intramembranous cleavage catalyzed by an aspartyl protease, γ-secretase. Two aspartates in presenilins (PS) are required for γ-secretase activity (D257 and D385 of PS1), suggesting th...

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Principais autores: Jun Wang, Anne L Brunkan, Silva Hecimovic, Emily Walker, Alison Goate
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2004-04-01
Serier:Neurobiology of Disease
Fag:
Alzheimer's disease
Presenilin
γ-secretase
APP
Aβ
Notch
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996103002730
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