Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity
γ-Secretase is a high molecular weight protein complex composed of four subunits, namely, presenilin (PS; 1 or 2), nicastrin, anterior pharynx defective-1 (Aph-1; A or B), and presenilin enhancer-2 (Pen-2), and is responsible for the cleavage of a number of type-1 transmembrane proteins. A fundament...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier
2004-11-01
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| Серии: | Neurobiology of Disease |
| Предметы: | |
| Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S0969996104001846 |
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