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Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

γ-Secretase is a membrane-associated protease that cleaves within the transmembrane region of amyloid precursor protein to generate the C termini of the two Aβ peptide isoforms, Aβ40 and Aβ42. Here we report the detergent solubilization and partial characterization of γ-secretase. The activity of so...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Li, Yue-Ming, Lai, Ming-Tain, Xu, Min, Huang, Qian, DiMuzio-Mower, Jillian, Sardana, Mohinder K., Shi, Xiao-Ping, Yin, Kuo-Chang, Shafer, Jules A., Gardell, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18571/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10801983/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110126897
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