Relation between viral fitness and immune escape within the hepatitis C virus protease

BACKGROUND: The hepatitis C virus (HCV) mutates within human leucocyte antigen (HLA) class I restricted immunodominant epitopes of the non‐structural (NS) 3/4A protease to escape cytotoxic T lymphocyte (CTL) recognition and promote viral persistence. However, variability is not unlimited, and someti...

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Autors principals: Söderholm, J, Ahlén, G, Kaul, A, Frelin, L, Alheim, M, Barnfield, C, Liljeström, P, Weiland, O, Milich, D R, Bartenschlager, R, Sällberg, M
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2006
Matèries:
Hepatitis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856491/
https://ncbi.nlm.nih.gov/pubmed/16105887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.072231
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