Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non‐polyposis colorectal cancer

BACKGROUND: Patients with early‐onset colorectal cancer (CRC) or those with multiple tumours associated with hereditary non‐polyposis colorectal cancer (HNPCC) raise suspicion of the presence of germline DNA mismatch repair (MMR) gene mutations. AIM: To analyse the value of family history, microsate...

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Autori principali: Niessen, R C, Berends, M J W, Wu, Y, Sijmons, R H, Hollema, H, Ligtenberg, M J L, de Walle, H E K, de Vries, E G E, Karrenbeld, A, Buys, C H C M, van der Zee, A G J, Hofstra, R M W, Kleibeuker, J H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2006
Soggetti:
Cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856475/
https://ncbi.nlm.nih.gov/pubmed/16636019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.090159
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