Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase

A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent wi...

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Bibliografiska uppgifter
Huvudupphovsmän: Kahn, Jennifer Nielsen, Garcia-Effron, Guillermo, Hsu, Ming-Jo, Park, Steven, Marr, Kieren A., Perlin, David S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2007
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855530/
https://ncbi.nlm.nih.gov/pubmed/17325225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00067-07
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