In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens

The activities of several tricyclic heteroaryl isothiazolones (HITZs) against an assortment of gram-positive and gram-negative clinical isolates were assessed. These compounds target bacterial DNA replication and were found to possess broad-spectrum activities especially against gram-positive strain...

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Bibliographic Details
Main Authors: Pucci, Michael J., Cheng, Jijun, Podos, Steven D., Thoma, Christy L., Thanassi, Jane A., Buechter, Douglas D., Mushtaq, Gohar, Vigliotti, Gerald A., Bradbury, Barton J., Deshpande, Milind
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855488/
https://ncbi.nlm.nih.gov/pubmed/17242152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01315-06
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