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Mechanistic Assessment of DNA Ligase as an Antibacterial Target in Staphylococcus aureus
We report the use of a known pyridochromanone inhibitor with antibacterial activity to assess the validity of NAD(+)-dependent DNA ligase (LigA) as an antibacterial target in Staphylococcus aureus. Potent inhibition of purified LigA was demonstrated in a DNA ligation assay (inhibition constant [K(i)...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3421614/ https://ncbi.nlm.nih.gov/pubmed/22585221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00215-12 |
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